Transcriptomic characterization of hepatobiliary plasticity of hepCLiPs and bilCLiPs

Recent studies have demonstrated extensive proliferative capacity of adult hepatocytes and biliary epithelial cells (BECs) in vitro, thereby allowing derivation of clonal cell lines named hepCLiPs and bilCLiPs, respectively. Both cell lines undergo hepatobiliary plastiticity in that they exhibit a BEC-like phenotype under a 2D culture condition, while they exhibit a hepatocyte-like phenotype under a 3D culture condition. This data set was obtained to comprehensively characterize the gene expression profiles of hepCLiPs and bilCLiPs which were cultured under 2D and 3D culture conditions. RNA was isolated from hepCLiPs and bilCLiPs which were either cultured under the 2D condition (hepCLiP_2D and bilCLiP_2D) or the 3D suspension condition (hepCLiP_3D and bilCLiP_3D).