Esr1

ENCODES a protein that exhibits DNA binding; enzyme binding; hormone binding; INVOLVED IN baculum development; cellular response to estradiol stimulus; cellular response to estrogen stimulus; PARTICIPATES IN estrogen signaling pathway; insulin-like growth factor signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH abnormal body size; abnormal female reproductive system morphology; abnormal male reproductive system morphology; ASSOCIATED WITH cryptorchidism; Diabetic Nephropathies; Experimental Diabetes Mellitus; FOUND IN nucleus; perikaryon; perinuclear region of cytoplasm; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane

编码一种具有DNA结合、酶结合、激素结合特性的蛋白质；参与阴茎发育、细胞对雌二醇刺激的响应、细胞对雌激素刺激的响应；参与雌激素信号通路、胰岛素样生长因子信号通路、磷脂酰肌醇3激酶-Akt信号通路；与异常体型、异常女性生殖系统形态、异常男性生殖系统形态相关；与隐睾症、糖尿病肾病、实验性糖尿病相关；存在于细胞核、细胞质周质、细胞核周围的细胞质区域；与（R,R,R）-α-生育酚、（S）-柚皮素、1,1,1-三氯-2,2-双（4-羟基苯基）乙烷相互作用。