Overview of the kinase domain amino acid changes in 26 predicted sites during type II functional divergence.

Sites that correlated with substantial biochemical change were detected in the pairwise type II functional analysis of the vertebrate IRAKs (KD). The residue numbering is based on the human IRAK4 KD sequence. The amino acid changes between the subfamilies along with their property changes are provided. (“+” represents a positive amino acid whereas “−” represents a negative amino acid).