A MISLEADING FORM OF IDIOPATHIC CAPILLARY LEAKAGE SYNDROME (CLARKSONS DISEASE): A CASE REPORT

The idiopathic capillary leak syndrome, commonly referred to as Clarksons disease, is an uncommon and severe disorder that frequently necessitates intensive care intervention due to recurring episodes of shock.With no established treatment available during the acute phase, the primary approach to management revolves around symptom relief. It seems that the use of vascular fluid resuscitation has an adverse effect on patient outcomes in intensive care, and therefore, there should be endeavors to restrict its usage.As an illustrative case, this article describes the case of a 53-year-old patient who presented to the emergency department with edema following the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and was initially misdiagnosed as anaphylaxis.Laboratory tests revealed hypoproteinemia in contrast to hemoconcentration, and the absence of serum albumin, which raised suspicion of Clarksons syndrome. This suspicion was confirmed through serum protein electrophoresis, ruling out other diagnoses.