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STAG2 Mutations Reshape the Cohesin-Structured Spatial Chromatin Architecture to Drive Gene Regulation in Acute myeloid Leukemia

NIAID Data Ecosystem2026-05-02 收录

癌症三维基因组学

急性髓系白血病表观遗传

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268035 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2024-08-06

急性髓系白血病表观遗传

治疗反应预测

BackgroundDNMT3A mutations occur in 20-25% of acute myeloid leukemia (AML) cases and are associated with poor prognosis, yet the epigenetic mechanisms underlying treatment response remain poorly under

NIAID Data Ecosystem80

Cis-Regulatory Element Hijacking by Structural Variants Overshadows Topological Changes in Primary Prostate Cancer. Cis-Regulatory Element Hijacking by Structural Variants Overshadows Topological Changes in Primary Prostate Cancer

癌症三维基因组学

顺式调控元件劫持

Prostate cancer is a heterogeneous disease whose progression is linked to genome instability. However, the impact of this instability on the non-coding genome and its three-dimensional organization to

NIAID Data Ecosystem50

Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques [Rec1_ChIP-seq]

癌症三维基因组学

Notch信号通路

Purpose: To investigate the impact of oncogenic Notch on the 3D genome organization of cancer cells. Methods: We generated cohesin HiChIP and 1D epigenomic data sets in two different Notch-dependent c

NIAID Data Ecosystem50

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

急性髓系白血病表观遗传

增强子靶向治疗

Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genes implic

NIAID Data Ecosystem80

Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia

急性髓系白血病表观遗传

SIRT6靶点机制

The FDA-approved DNA hypomethylating agents (DHAs) like 5-azacytidine (5AC) and decitabine (DAC) demonstrate efficacy in the treatment of hematologic malignancies. Despite previous reports that showed

NIAID Data Ecosystem50

STAG2 Mutations Reshape the Cohesin-Structured Spatial Chromatin Architecture to Drive Gene Regulation in Acute myeloid Leukemia

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