Scalable C–H Oxidation with Copper: Synthesis of Polyoxypregnanes
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https://figshare.com/articles/dataset/Scalable_C_H_Oxidation_with_Copper_Synthesis_of_Polyoxypregnanes/2114131
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资源简介：
Steroids
bearing C12 oxidations are widespread in nature, yet only
one preparative chemical method addresses this challenge in a low-yielding
and not fully understood fashion: Schönecker’s Cu-mediated
oxidation. This work shines new light onto this powerful C–H
oxidation method through mechanistic investigation, optimization,
and wider application. Culminating in a scalable, rapid, high-yielding,
and operationally simple protocol, this procedure is applied to the
first synthesis of several parent polyoxypregnane natural products,
representing a gateway to over 100 family members.
创建时间：
2016-02-12
