Aminooxylation Horner–Wadsworth–Emmons Sequence for the Synthesis of Enantioenriched γ‑Functionalized Vinyl Sulfones
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https://figshare.com/articles/dataset/Aminooxylation_Horner_Wadsworth_Emmons_Sequence_for_the_Synthesis_of_Enantioenriched_Functionalized_Vinyl_Sulfones/2081182
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资源简介：
An operationally simple protocol
for the synthesis of γ-hydroxy
vinyl sulfones has been developed using a proline-based aldehyde aminooxylation,
followed by a vinyl sulfone forming Horner–Wadsworth–Emmons
olefination. The adducts, formed in high enantiopurity, were subsequently
converted to γ-azido vinyl sulfones, and azide–alkyne
click chemistry enabled the synthesis of vinyl sulfone-based triazoles
as potential nonpeptidic cysteine protease inhibitors.
创建时间：
2016-02-12
