Association between long-term occupational exposure to PM10 and allergic diseases in subway workers - Switzerland, France

Name: Association between long-term occupational exposure to PM10 and allergic diseases in subway workers - Switzerland, France
Creator: data.unisante.ch
Published: 2024-03-04 00:00:00
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Abstract --------------------------- Background: Long-term exposure to ambient particulate matter (PM) in adults increases the risk of allergic diseases exacerbation. We evaluated whether a long-term occupational exposure to subway PM10 is associated with the prevalence of atopic sensitization and allergic diseases (i.e., current asthma, current rhinitis or current eczema) and whether the latter are associated with biomarkers measured in exhaled breath condensate (EBC) of subway workers. Methods: Participants were randomly selected from a 15,000-subway worker cohort. Individual inhaled PM10 mass (iPM10) per shift at work was estimated using a company-specific job-exposure-matrix based on PM10 measurements conducted between 2004 and 2019. iPM10 was modelled as function of PM10 exposure averaged over the participant’s employment in the Parisian subway, inhalation rate, and filtration efficiency of the respiratory protection used. Atopic sensitization was tested using skin prick tests. Allergic diseases were assessed using self-administered questionnaire. Associations were assessed using multivariable logistic regression models adjusted for potential confounders. Results: Amongst 287 participants, 39% had an atopic sensitization, 25% a poly-atopic sensitization, 5 Analysis unit --------------------------- The unit of analysis is the individual. The number of participants is 287. Kind of data --------------------------- This repository is meant to share additional material for the article. All data and biological samples were collected from March through May 2021 according to the study protocol (Guseva Canu I, Hemmendinger M, Sauvain JJ, Suarez G, Hopf NB, Pralong JA, et al. Respiratory Disease Occupational Biomonitoring Collaborative Project (ROBoCoP): A longitudinal pilot study and implementation research in the Parisian transport company. J Occup Med Toxicol. 2021;16(1):22.). The data can not be shared. Mode of data collection --------------------------- Other [oth]

摘要 --------------------------- 背景：成年人长期暴露于环境颗粒物（PM）会增加过敏性疾病的恶化风险。本研究旨在评估长期职业暴露于地铁PM10是否与特应性敏感化和过敏性疾病的流行（即当前哮喘、当前鼻炎或当前湿疹）相关，以及后两者是否与地铁工人呼出气冷凝液（EBC）中测量的生物标志物相关。方法：参与者从15,000名地铁工人队列中随机选取。根据2004年至2019年间进行的PM10测量结果，使用公司特定的职业暴露矩阵估计每个班次的工作中个体吸入PM10质量（iPM10）。iPM10被视为参与者巴黎地铁工作期间PM10平均暴露量、吸入速率以及呼吸防护用品过滤效率的函数。通过皮肤点刺试验测试特应性敏感化。使用自填问卷评估过敏性疾病。通过调整潜在混杂因素的多元逻辑回归模型评估关联。结果：在287名参与者中，39%有特应性敏感化，25%有多特应性敏感化，5... 分析单元 --------------------------- 分析单元为个体。参与者数量为287。数据类型 --------------------------- 本存储库旨在分享文章的额外材料。所有数据和生物样本均按照研究方案（Guseva Canu I, Hemmendinger M, Sauvain JJ, Suarez G, Hopf NB, Pralong JA, 等人. 呼吸道疾病职业生物监测协作项目（ROBoCoP）：巴黎交通公司的纵向试点研究和实施研究。J Occup Med Toxicol. 2021;16(1):22.）于2021年3月至5月收集。数据无法共享。数据收集方式 --------------------------- 其他[oth]

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