首页/数据集/BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells. BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells

BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells. BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells

NIAID Data Ecosystem2026-03-11 收录

CAR-NKT细胞疗法

T细胞耗竭

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA647363 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2020-07-20

CAR-NKT细胞疗法

免疫毒性

CD19-directed chimeric antigen receptor (CAR) T-cell therapy has been widely used and highly effective for B-cell lymphoid malignancies. Immune-mediated adverse effects such as cytokine release syndro

DataCite Commons2023-04-21 更新80

scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection. scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection

T细胞耗竭

免疫单细胞多组学

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem50

Homo sapiens Transcriptome or Gene expression

CAR-NKT细胞疗法

实体瘤靶向治疗

The clinical application of chimeric antigen receptor (CAR) T cell therapy in solid tumors remains limited due to significant safety concerns, particularly "on-target, off-tumor" toxicity and cytokine

NIAID Data Ecosystem30

scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

肿瘤免疫

T细胞耗竭

CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors

NIAID Data Ecosystem60

IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity. IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity

CAR-NKT细胞疗法

肿瘤免疫微环境

Chimeric antigen receptor (CAR) T cells mediate potent antigen-specific antitumor activity, however, their indirect effects on the endogenous immune system is not well characterized. Remarkably, we de

NIAID Data Ecosystem30

BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells. BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells

资源简介：

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