The histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target in BRAF/MEK inhibitor-resistant melanoma [HT144]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109669
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The aim of this work is to establish the impact of SETDB1 expression in melanoma. SETDB1 was overexpressed in melanoma cell lines (SETDB1 OE) and whole-genome expression profiles were compared to the control ( melanoma cells carrying an empty vector). Total RNA from SETDB1 overexpressing HT144 melanoma cells was compared to HT144 melanoma cells carrying an empty vector (control) and mutant HC/KA-SETDB1 overexpressing HT144 melanoma cells.
创建时间：
2020-03-31
