Whole-exome sequencing of 28 paired large cell lung cancer samples and normal lung tissues. Homo sapiens

We report the identification of somatic mutations for large cell lung cancer in 28 tumor-normal pairs through exome sequencing. These genes were sequenced by whole-exome sequencing with a mean depth of 68.81×. There were a variety of types of mutations identified, with T > A transversion being the most common nucleotide substitution.After filter analysis and exclusion of synonymous mutations, the numbers of indels and non-synonymous SNVs were calculated. In addition to some previously reported mutations, such as those in TP53, APC, KRAS, and PIK3CA5, we identified a lot of point mutations only existed in large cell lung cancer.