EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE136216
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We investigated the function of EGR1 in macrophage differentiation and activation. We generated EGR1 CHIP-seq and CUT-and-RUN data during GM-CSF induced macrophage differentiation, paired with ATAC-seq. We performed RNA-seq and CHIP-seq for H3K27ac in EGR1-depleted differentiated macrophages. Finally we generated RNA-seq data in activated macrophages with EGR1 overexpression. Analysis of genome-wide activity of EGR1 in macrophage differentiation.
创建时间：
2021-02-08
