five

Cdk5 regulates activity-dependent gene expression and dendrite development [cultured cortical neurons]

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68320
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To investigate the molecular mechanism underlying activity-dependent dendrite development regulated by Cdk5, an unbiased microarray analysis was performed to identify activity-dependent genes differentially regulated in cortical neurons from E18 Cdk5-knockout embryos. Cortical neurons were cultured from E18 Cdk5-knockout embryos and littermates. RNA was extracted and analyzed at 5 days in vitro (DIV) by the GeneChip® WT PLUS Reagent Kit (WT PLUS Kit, Affymetrix) according to the manufacturer’s instructions.
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2015-12-11
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