Hydroamination of Alkynes Catalyzed by Imido Complexes of Titanium and Vanadium

Intermolecular alkyne hydroamination with primary amines is catalyzed with group 5
(vanadium and tantalum) transition metal complexes and a new imido-Ti(IV) complex. The
reaction is very regioselective. The scope of the reaction was investigated with a variety of
alkynes and amines; 1-hexyne and anilines were found to be especially good substrates.