Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents
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https://figshare.com/articles/dataset/Design_Synthesis_and_Biological_Evaluation_of_Combretabenzodiazepines_A_Novel_Class_of_Anti_Tubulin_Agents/2196532
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资源简介：
In
the present manuscript, starting from the 1,4-benzodiazepin-2-one
nucleus, a privileged structure in medicinal chemistry, we have synthesized
a novel class of cis-locked combretastatins named combreatabenzodiazepines.
They show similar cytotoxic and antitubulin activity compared to combretastatin
A-4 in neuroblastoma cells, showing a better pharmacokinetic profile.
This class of compounds has therefore the potential for further development
as antitubulin agents.
创建时间：
2016-02-14
