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Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

NIAID Data Ecosystem2026-05-01 收录

红细胞生成调控

表观遗传甲基化

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE222115 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-01-01

表观遗传甲基化

心脑血管疾病生物标志物

Differentially methylated genes with Target ID, Gene ID, chromosome location, % methylation change and FDR p-value for each gene methylated. CpG sites with significant FDR p-value indicating methylati

NIAID Data Ecosystem60

ATAC-seq reveals GATA-1- and heme-dependent chromatin targeting in erythroid cells.

红细胞生成调控

染色质可及性分析

CRISPR/Cas9-mediated ablation of two Alas2 intronic cis-elements in G1E-ER-GATA1 cells strongly reduced GATA-1-induced Alas2 transcription, heme biosynthesis, and GATA-1 regulation of other vital cons

NIAID Data Ecosystem50

Ypel4-null Mice Display Secondary Polycythemia Associated with Ovalocytosis and Lower Band 3 Protein Levels on Red Blood Cells

红细胞生成调控

红细胞膜蛋白功能

The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms and thus potentially involved in essential cellular processes. Ypel4, one of five YPEL family gene orthologs i

NIAID Data Ecosystem20

Table_1_Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics.DOCX

红细胞生成调控

线粒体动力学

Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) gener

NIAID Data Ecosystem60

Transcriptome analysis of erythroblastic island macrophages. Transcriptome analysis of erythroblastic island macrophages

造血微环境

红细胞生成调控

The erythroblastic island (EBI), composed of a central macrophage and surrounding erythroid cells, was the first hematopoietic niche discovered. The identity of EBI macrophages has thus far remained e

NIAID Data Ecosystem30

Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

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