Supplementary file 1_Analyzing EEG data during opium addiction treatment using a fuzzy logic-based machine learning model.docx

BackgroundReliable noninvasive tools for assessing substance abuse treatment and predicting outcomes remain a challenge. We believe EEG-derived complexity measures may have a direct link to clinical diagnosis. To this aim, our study involved a psychological investigation of four groups of current and former male opium addicts. Furthermore, we propose a machine learning (ML) model incorporating fuzzy logic to analyze EEG data and identify neural complexity changes associated with opium addiction.
MethodMale participants were categorized into four groups: active addicts, those with less than three days of treatment, those treated for over two weeks, and healthy controls. Psychological assessments evaluate mental health and addiction status. EEG data were collected using standardized electrode placement, preprocessed to remove noise, and analyzed using the Higuchi Fractal Dimension(HFD) to quantify neural complexity. Feature selection methods and ML classifiers were applied to identify key patterns distinguishing addiction stages.
ResultsDistress levels varied significantly across groups and persisted post-quitting. Addicts exhibited poorer general health than controls, though treatment led to improvements. Significant differences in neural complexity were observed in brain regions linked to attention, memory, and executive function. The ML model effectively classified addiction stages based on EEG-derived features.
ConclusionThis study demonstrates the potential of ML and fuzzy logic in assessing addiction-related neural dynamics, offering insights into opioid addiction’s pathophysiology. The findings highlight the promise of brainwave-based biomarkers for personalized addiction diagnosis and treatment monitoring.