Screening radiation-differentially expressed circular RNAs and establishing dose classification models in the human lymphoblastoid cell line AHH-1

To investigate whether circRNAs have the potential for being radiation biomarker,we screened the radiation-induced differential expressed circRNAs in the AHH-1 cell line exposed to 60Co ? rays. And we established 4 expression models for radiation dose estimation by use of the validated radiation-induced differential expressed circRNAs. Overall design: radiation-induced differential expressed circRNAs were screened through transcriptome sequencing with human lymphoblastoid cell line AHH-1 at 4 h after irradiated with 0, 2, and 5 Gy 60Co ?-rays.