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Circadian Cryptochrome 1 (CRY1) Rhythmically Modulates the DNA Damage Response [RNA-seq]

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NIAID Data Ecosystem2026-03-12 收录
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These studies identify a novel node of AR-regulated DNA repair through CRY1 directly regulating HR-mediated DNA repair to enhance cancer progression and discern a potential avenue to be targeted in late stage disease to improve patient outcome. Transcriptional alterations upon CRY1 loss were assessed in hormone proficient conditions through RNA-Seq of C4-2 shCON and C4-2 shCRY1 prostate cancer cells

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2021-01-27
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