Adjusted^a estimates of the mean percent difference of HRV associated with a 1 µg/m³ increase in average exposure to traffic-related PM10^b by <i>IL6</i>-174 G/C genotypes (N = 1549).

HRV indicates heart rate variability: SDNN indicates standard deviation of all NN intervals (units ms); TP, total power (ms2); HF, high frequency power (ms2); LF, low frequency power (ms2). aadjusted for gender, age, age squared, BMI, BMI squared, smoking status, environmental tobacco smoke exposure, alcohol consumption, physical activity, high-sensitivity C-reactive protein, uric acid levels, hypertension, heart disease, diabetes, street and railway noise, seasonal effects and area. bAnnual average over 10 years previous to the study. cp-values for the genotype- specific TPM10 effect estimate. dp-values of interaction effects of the IL6-174 G/C polymorphism with TPM10 on HRV were tested for additive, dominant and recessive genetic models; p-values of the most significant mode of inheritance are presented (additive1 or dominant2).