Prediction of the prionic behaviour of putative Q/N rich yeast prions.

Prion recovery using the prion/non-prion (NP/P) classification of selected putative prions according to Alberti's scale of prion activity. Sequences with pWALTZ score >73.55 are considered prion-like. False positives and false negatives are underlined. Proteins devoid of any predicted amyloid core are shown in italics (SUP35, in plain text, was not included in the test set to avoid overlap with the WALTZ training set). (b) Prion/Non-Prion (P/NP) classification according to Alberti et. al. scale of prion propensity (Cell 137, 146–158). Sequences scoring ≤2 (1 positive assay as a maximum) are considered non-prions (NP) while sequences scoring ≥9 (all four asays positives) are considered prions (P). Prediction of the prionic behaviour of putative Q/N rich yeast prions.