DNA-damage induced differentiation of leukemic cells as an anti-cancer barrier

ChEBI2014-07-22 更新2026-07-21 收录

白血病细胞分化

DNA损伤抗癌机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-57147 数据链接链接失效反馈

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DNA-damage induced differentiation of leukemic cells as an anti-cancer barrier

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2014-07-22

The role of TFEB in retinoid induced differentiation of NB4 APL leukemic cells (shTFEB). Homo sapiens

白血病细胞分化

转录因子功能研究

We report the use of RNAseq to determine the role of the TFEB transcription factor in all-trans retinoic acid induced differentiation of NB4 acute promyelocytic leukemia (APL) cells. We used lentivira

NIAID Data Ecosystem70

Long Intergenic Non-Coding RNA HOTAIRM1 Regulates Cell Cycle Progression During Myeloid Maturation in NB4 Promyelocytic Leukemia Cells

白血病细胞分化

非编码RNA调控

HOTAIRM1 is a long intergenic non-coding RNA located in the human HOXA gene cluster, with gene expression highly specific for maturing myeloid cells, particularly during all-trans retinoic acid (ATRA)

NIAID Data Ecosystem40

Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G(1)

白血病细胞分化

细胞周期蛋白依赖性激酶抑制

Some tumor cells can be stimulated to differentiate and undergo terminal cell division and loss of tumorigenicity. The in vitro differentiation of murine erythroleukemia (MEL) cells is a dramatic exam

PubMed Central2000-12-12 更新20

Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition [miRNA]

白血病细胞分化

RNA调控网络

Treatment of leukemia cells with 1,25-dihydroxyvitamin D3 may overcome their differentiation block and lead to the transition from myeloblasts to monocytes. To identify microRNA-mRNA networks relevant

NIAID Data Ecosystem50

Abemaciclib induces LSCs differentiation

白血病细胞分化

药物机制研究

abemaciclib drives differentiation of acute myeloid leukemia stemcells

NIAID Data Ecosystem40