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Adverse Outcome Pathway on Alkylation of DNA in Male Pre‑Meiotic Germ Cells Leading to Heritable Mutations

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Germ cell/heritable mutations are important regulatory endpoints for international agencies interested in protecting the health of future generations. However, germ cell mutation analysis has been hampered by a lack of efficient tools. The motivation for developing this AOP was to provide context for new assays in this field, identify research...

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