Summary of clinical AEs by cohort^a.

Abbreviations: AE, adverse event. aExpressed as n and percent of total subjects in each cohort. bAE led to discontinuation by subject owner, not by investigator. c0.007×1 mg/kg cohort: Demodex canis at day 44 post 0.5 mg/kg prednisolone on days 0 to 14; and 0.007×2 mg/kg cohort: Demodex injai at day 56 post 1.0 mg/kg prednisolone on days 0 to 14. Demodicosis cleared after one dose of milbemycin oxime, and each subject treated with LD-aminopterin for 24 (0.007×1 mg/kg cohort) and 9 (0.007×2 mg/kg cohort) months in the open-label segment without recurrence. Summary of clinical AEs by cohorta.