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2023-02-16
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Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells. Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells
Single-cell RNA sequencing in principle offers unique opportunities to improve the efficacy of contemporary T-cell based immunotherapy against cancer. The use of high-quality single-cell data will aid
NIAID Data Ecosystem40
Table1_Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs.xlsx
BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the
NIAID Data Ecosystem30
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors
A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective
NIAID Data Ecosystem20
Antibody Recognition of Cancer-Related Gangliosides and Their Mimics Investigated Using in silico Site Mapping
Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is
Figshare2012-04-20 更新30
Table_1_Surfaceome Proteomic of Glioblastoma Revealed Potential Targets for Immunotherapy.xlsx
Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults. The mortality rate is very high despite different treatments. New therapeutic targets are therefore highly needed
NIAID Data Ecosystem20
