Cox regression analyses of association between gene expression and PFS and OS (HR per 1-unit increase), and correlation with nuclear TS expression for 9 genes significantly associated with both PFS and OS (N = 51 patients with nsNSCLC).

Derived from mRNA profiling data using the Almac Lung Cancer-DSA microarray (1,030 selected genes) [11]. FDR was calculated across 1,030 genes for each endpoint. *unadjusted p<0.01 for Spearman correlation between TS nucleus expression assessed by IHC. Abbreviations: FDR, False Discovery Rate; HR, hazard ratio; IHC, immunohistochemistry; IL, interleukin; N, number of patients; NKX2-1, NK2 homeobox 1; nsNSCLC, non-squamous non-small cell lung cancer; OS, overall survival; PFS, progression-free survival; R, spearman correlation coefficient; TS, thymidylate-synthase; TTF-1, transcription factor 1. Cox regression analyses of association between gene expression and PFS and OS (HR per 1-unit increase), and correlation with nuclear TS expression for 9 genes significantly associated with both PFS and OS (N = 51 patients with nsNSCLC).