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Per-sample data for: Transferability Limits of Published qNet Risk Thresholds Across Sex and Heart Failure in Ventricular Substrates

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Zenodo2026-08-19 更新2026-08-20 收录
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Simulation output underlying every figure and table of the manuscript "Transferability Limits of Published qNet Risk Thresholds Across Sex and Heart Failure in Ventricular Substrates". Single-cell O'Hara-Rudy simulations, CiPA-optimised variant of Dutta et al. 2017, paced at a basic cycle length of 2,000 ms (0.5 Hz) for 1,000 beats, with biomarkers taken from the final beat. Twelve ventricular substrates are formed from four sex-by-disease phenotypes crossed with three transmural layers. Drug potency was resampled 2,000 times per condition by parametric bootstrap over the IC50 values of Kramer et al. 2013. Contents, 139 files: per_sample/ 96 files, one per layer / drug / concentration / phenotype, 2,000 rows each, one row per uncertainty-quantification sample summaries/ 24 files, per-condition minimum, maximum and median with the change from the matching drug-free baseline traces/ 12 files, full current traces for the drug-free substrates baselines/ 3 files, the twelve drug-free substrates, one row per phenotype thresholds.csv the published per-cell-type qNet decision thresholds reproduce.py recomputes the manuscript's risk classification, drug-free control, charge decomposition and baseline-versus-drug comparison, using only the Python standard library README.md full column definitions, provenance and three cautions LICENSE.txt CC BY 4.0 Compounds: mitoxantrone at 800, 1600, 2400 and 3200 nM, and ribavirin at 2,500, 5,000, 7,500 and 10,000 nM. That is 96 drug conditions and 192,000 drug-exposed beats, plus twelve drug-free baselines. Every label is carried in a filename or a column, never by row or directory position. Concentrations in path names are nanomolar. Files are restricted pending publication of the associated manuscript. Version `1.0.0`

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2026-08-19
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