ESI: Multifunctional nanocarriers of Fe3O4@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery - Supplementary dataset

Background: Despite medicinal advances, cancer is still a big problem requiring better diagnostic and
treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were
developed for these unmet needs. Methods: This study fabricated novel trifunctionalMNPs of Fe3O4@PLAPEG
for drug release, MRI and magnetic fluid hyperthermia. Result: The MNPs provided a significant
loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g
and significantly increased transverse relaxivity (r2 = 364.75 mM-1 s-1). The in vivo study confirmed that
the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could
effectively reduce the tumor size in mice bearing sarcoma 180. Conclusion: The nanocarrier has potential
for drug release, cancer treatment monitoring and therapy.