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JPST000123-5 ATPome-wide selectivity profiling of (s)-crizotinib [Reanalysis: JPST000123]

NIAID Data Ecosystem2026-03-14 收录

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药物靶点分析

数据链接：

https://www.omicsdi.org/dataset/jpost/RPXD034291 数据链接链接失效反馈

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资源简介：

ATPome-wide selectivity profiling of a kinase inhibitor (s)-crizotinib [Original project description]

应用场景：

创建时间：

2023-03-25

靶向抗肿瘤药物设计

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Heparanase is the sole mammalian enzyme capable of cleaving glycosaminoglycan heparan sulfate side chains of heparan sulfate proteoglycans. Its altered activity is intimately associated with tumor gro

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Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis

阿米巴病药物开发

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Background Amoebiasis, caused by Entamoeba histolytica infection, is a global public health problem. However, available drugs to treat amoebiasis are currently limited, and no effective vaccine exists

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U2OS cell line -SpCas9 inhibitor- Raw sequence reads

CRISPR-Cas9基因编辑

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To detect the cleavage activity of SpCas9 in U2OS after treat with small molecular inhibitor of SpCas9

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QL-XII-47 KINOMEscan

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药物靶点结合检测

The KINOMEscan assay platform is based on a competition binding assay that is run for a compound of interest against each of a panel of 317 to 456 kinases. The assay has three components: a kinase-tag

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Activity comparison for TBK1 and IKKε.

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药物发现

Number of active compounds (N) detected in each screen for total number detected (unfiltered), number after drug like filtering (filtered.drug-like), hits from the LOPAC and Kinase libraries, and the

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JPST000123-5 ATPome-wide selectivity profiling of (s)-crizotinib [Reanalysis: JPST000123]

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