Cardiomyocyte peroxisome proliferator-activated receptor a prevents septic cardiomyopathy via improving mitochondrial function

Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondrial function is essential for cardiomyocyte homeostasis as disrupted mitochondrial dynamics enhances mitophagy and apoptosis. However, therapies targeted to improve mitochondrial function in septic patients have not been explored. Our research is helpful to understand the role of cardiomyocyte PPARa in LPS-induced cardiac dysfunction Overall design: In this study, we isolated heart tissue from PBS- or LPS- treated Ppara-Flox and cardiomyocyte PPARa deficient mice (4 samples each) were subjected to RNA sequencing.