Tipping point in alpha-synuclein-membrane interactions from stable protein-covered vesicles to amyloid aggregation

HSQC_20C and HSQC_t37C folder contains raw 1H-15N HSQC data acquired on samples containing a-synuclein and SUVs at different lipid-to-protein (L/P) ratios at 20 and 37 degrees C. DiffusionNMR contains diffusion NMR raw data acquired on a-synuclein and SUVs at different L/P ratios at 20 degrees C. The data are analyzed, presented and discussed in Makasewicz et al. (https://doi.org/10.1016/j.xcrp.2024.102309).
The folder matlabScript contains all Matlab codes used to simulate NMR spectra, which are shown in the Supplemental Information.

HSQC_20C与HSQC_t37C文件夹包含了在20℃和37℃下，于含有α-突触核蛋白和SUVs的样本中，不同脂质与蛋白（L/P）比例下采集的1H-15N HSQC原始数据。DiffusionNMR文件夹包含了在20℃下，于α-突触核蛋白和SUVs的不同L/P比例下采集的扩散核磁共振（NMR）原始数据。这些数据经Makasewicz等人（https://doi.org/10.1016/j.xcrp.2024.102309）分析、展示和讨论。文件夹matlabScript中包含了用于模拟NMR光谱的所有Matlab代码，这些代码见补充信息。