The Blood Exposome Database

The exposome represents the sum of all exposures during the life-span of an organism (from chemicals to microbes, viruses, radiation and other sources). Exposome chemicals are a major component of the exposome and are known to alter activities of cellular pathways and structures. In humans, exposome chemicals are transported throughout the body, linking chemical exposures to phenotypes such as such as cancer, ageing or diabetes. The Blood Exposome DB is a collection of chemical compounds and associated information that were automatically extracted by text mining the content of PubMed and PubChem databases. The database also unifies chemical lists from metabolomics, systems biology, environmental epidemiology, occupational expossure, toxiology and nutrition fields.暴露组（exposome）指生物体整个生命周期内所经历的全部暴露的总和，覆盖化学物质、微生物、病毒、辐射及其他各类暴露源。暴露组化学物是暴露组的核心组成部分，已知其可改变细胞通路与细胞结构的活性。在人体中，暴露组化学物可随血液循环遍布全身，将化学暴露与癌症、衰老、糖尿病等表型关联起来。血液暴露组数据库（Blood Exposome DB）是一类化合物及其关联信息的集合，其数据通过文本挖掘PubMed与PubChem数据库的内容自动提取获得。该数据库还整合了来自代谢组学、系统生物学、环境流行病学、职业暴露、毒理学及营养学领域的化学物列表。

搜集汇总

背景与挑战

背景概述

血液暴露组数据库是一个通过先进文本挖掘技术构建的综合目录，系统收录了人类血液中报告的化学物质，数据来源于NCBI PubChem、PubMed等科学数据库以及原始研究、生物监测调查和公共代谢组学数据集。该数据库旨在为科研和临床领域提供可靠、全面的化学暴露资源。