High-risk HPV (hrHPV) Prevalence and Effectiveness of HPV Vaccination Under Different Vaccination Scenarios.

The prevalence refers to hrHPV prevalence among females 10–70 years of age. Base-case vaccination scenario: 80% vaccination coverage among women; wide range of type-specific protection (Table 1); 20 years duration of vaccine induced protection waning on average in the next 20 years. Lower cross-protection: vaccine efficacy 50% against type 31, and 0% against other non-vaccine types; Shorter protection: 10 years duration of vaccine induced protection waning on average in the next 10 years; G/B the coverage of vaccination for girls/boys. High-risk HPV infection includes both transient and persistent infections (Pers.inf.). The effectiveness of HPV -vaccination is defined as a relative reduction in the corresponding prevalence (post-vaccination vs pre-vaccination era).