LIG3

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

本基因属于DNA连接酶家族。该家族的每一成员编码的蛋白均催化DNA末端的连接，但它们在DNA代谢中各自扮演着独特的角色。由本基因编码的蛋白参与切除修复过程，并存在于线粒体和细胞核中。上游起始密码子的翻译起始允许其转运至线粒体，而下游起始密码子的翻译起始则允许其转运至细胞核。此外，已鉴定出多种转录剪接变异体，编码不同的同种异构体。[由RefSeq提供，2008年7月]