Data_Sheet_1_VGLUT2 Functions as a Differential Marker for Hippocampal Output Neurons.PDF

The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

海马与皮层区域之间的过渡区域为海马旁回。然而，由于缺乏特异性标记基因，对海马旁回区域的分析变得尤为困难。本研究报道了囊性谷氨酸转运蛋白2（VGLUT2）作为海马旁回爆发性放电神经元的特异性标记基因的功能，并展示了VGLUT2-Cre小鼠在ChR2辅助下的连接分析得以实现。