The effect of oncogenic KrasG12D on the expression of inflammation-related genes in myeloid cells. The effect of oncogenic KrasG12D on the expression of inflammation-related genes in myeloid cells

Oncogenic Ras mutations occur frequently in hematological malignancies. It was unclear if besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the development of the disease. We used microarray-based analysis of murine hematopoietic bone marrow (BM) cells harboring active inducible KrasG12D to reveal the expression of inflammation-related genes. Overall design: 8 samples each of them from an individual mouse (biological replicate) were analyzed