Study of heavy metal stress in the basidiomycete Schizophyllum commune

Transcriptome changes associated with metal stress were investigated in order to identify tolerance mechanisms and the impact on inositol signaling. The wild type S. commune 12-43 was compared with 12-43 grown with addition of contaminated seepage water (HSW) and another wild type strain W22 grown with 0.01 mM Cd. With microarray analysis, the mRNA expression pattern of heavy metal response was analyzed. The comparisons between the strain 12-43 and 12-43 grown on contaminated seepage water (HSW) and 12-43 with W22 grown with 0.01 mM Cd were observed. For each comparison two replicates were analyzed.