Data From: Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM phosphorylation

Tabular raw data corresponding to figure sets used in the study. Figure 1: ERM phosphorylation is impaired in PD patients carrying LRRK2 G2019S mutation. Figure S1 (Related to Figure 1): Phospho-ERM is upregulated in LRRK2 G2019Ski/ki astrocytes in ACC and MOp but not SSp and DMS. Figure S2 (Related to Figure 1): GFAP level is not altered in LRRK2 G2019Ski/ki astrocytes in ACC and MOp. Figure 2: LRRK2 G2019S affects excitatory and inhibitory synapse numbers in the ACC and MOp. Figure S3 (Related to Figure 2): LRRK2 G2019S does not change excitatory synapse numbers in the primary motor cortex. Figure 3: LRRK2 G2019S affects excitatory and inhibitory synapse function in the ACC and MOp. Figure 4: Overexpression of phospho-dead Ezrin in adult LRRK2 G2019Ski/ki astrocytes restores excitatory synapse number and function in the ventral ACC. Figure S4 (Related to Figure 4): Overexpression of AAV-HA-tagged-WT Ezrin and AAV-HA-tagged-Phospho-dead Ezrin in WT and LRRK2 G2019Ski/ki astrocytes. Figure S5 (Related to Figure 4): Overexpression of AAV-HA-tagged-WT Ezrin and AAV-HA-tagged-Phospho-dead Ezrin in WT and LRRK2 G2019Ski/ki astrocytes. Figure 5: Astrocytic LRRK2 controls astrocyte morphology by balancing ERM phosphorylation levels in vivo. Figure S6 (Related to Figure 5): LRRK2 G2019S does not change ALDH1L1+/SOX9+ cell numbers in the ACC and MOp. Figure S7 (Related to Figure 5): Localization and expression of LRRK2 in astrocytes. Figure 6: LRRK2 G2019S alters the interactome of astrocytic Ezrin in vivo. Figure S9: LRRK2 G2019S changes the composition of cytoplasmic proteins in astrocytes in vivo. Figure 7: Interaction Between Atg7 and Ezrin Depends on Ezrin's Phosphorylation State. Figure S10: Astrocytic Atg7 is essential astrocyte morphological complexity in vitro.