Crystal structure of Dot1l in complex with a brominated SAH analog
收藏Protein Data Bank Japan2023-09-13 更新2026-03-21 收录
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Crystal structure of Dot1l in complex with a brominated SAH analog Descriptor: (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid (non-preferred name), Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... Authors: Yu, W, Tempel, W, Smil, D, Schapira, M, Li, Y, Vedadi, M, Nguyen, K.T, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Brown, P.J, Structural Genomics Consortium (SGC) Deposit date: 2011-07-14 Release date: 2011-07-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorg. Med. Chem., 21, 2013
创建时间：
2011-07-14
