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Our study highlights the relevance of H2Bub in transcription. Cells lacking the DUBs Ubp8 or Ubp16 display enhanced tolerance to stress thanks to the basal and induced up-regulation of stress genes. Accumulation of this histone mark at promoters in cells lacking the DUB Ubp8 is sufficient to promote Pol II transcription even in the absence of H3K9 acetylation or H3K4 methylation. In contrast, the phenotypes of strain Δ<i>ubp16 </i>are suppressed by the lack of other histone writers. We believe that these findings may open the door to understanding the complex cross-talk between histone PTMs and Pol II transcription.