Exposure of PBMCs to SARS-CoV-2, as opposed to SARS-CoV, induces cell-intrinsic type I innate immunity responses in several immune cell types in the absence of productive infection. Exposure of PBMCs to SARS-CoV-2, as opposed to SARS-CoV, induces cell-intrinsic type I innate immunity responses in several immune cell types in the absence of productive infection

We investigate the response of peripheral blood mononuclear cells (PBMCs) to SARS-CoV and SARS-CoV-2 exposure. Overall design: RT-qPCR, western blotting and single cell RNA sequencing was peformed on PBMCs exposed ex vivo to SARS-CoV and SARS-CoV-2 virus or mock exposed.