A Cyclopentane Conformational Restraint for a Peptide Nucleic Acid: Design, Asymmetric Synthesis, and Improved Binding Affinity to DNA and RNA
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https://figshare.com/articles/dataset/A_Cyclopentane_Conformational_Restraint_for_a_Peptide_Nucleic_Acid_Design_Asymmetric_Synthesis_and_Improved_Binding_Affinity_to_DNA_and_RNA/3747429
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资源简介：
A strategy to restrict the highly flexible backbone conformation of a peptide nucleic acid (PNA) by incorporation of a cyclopentane ring is
proposed. An asymmetric synthesis of cyclopentane-modified PNA is reported, and its binding properties were determined. The cyclopentane
ring leads to a significant improvement in the binding properties of the resulting PNA to DNA and RNA.
创建时间：
2016-08-20
