Demographics and clinical status of patients used in discovery-driven approach.

Dyes were swapped for one CR and one CNR to remove dye bias.*Relapses before and after are the annualised relapse rates before and after commencement of IFNβ treatment respectively for RRMS patients. EDSS before and after gives annual EDSS score before and after the last year of IFNβ therapy respectively for SPMS patients.