Estimated selection coefficients.

Comparison of Ne-ABC and Malaspinas et al.[32] estimates of s for the significant trajectories under selection. Bold indicates nonsynonymous mutations and italic indicates a poor fit to our Wright-Fisher model. We indicate the nucleotide corresponding to the minor allele, with its initial frequency at the beginning of the experiment in the absence of oseltamivir, or at passage 4 when drug treatment began (see Figure 1). For the Ne-ABC method, we give the 99% highest posterior density intervals (HPDIs) in brackets.