Nuclear Actin Regulates Inducible Transcription by Enhancing RNA Polymerase II Clustering

Nuclear actin dynamics regulate enhanced RNA polymerase II clustering on specific genes upon serum stimulation, thus establishing the serum-induced transcriptional program. We sequenced the transcriptomes of U2OS cells overexpressing actin mutant G13R and those expressing GFP as control, at both normal-growth and serum-stimulation conditions.