Catalytically Asymmetric Synthesis of 1,3-Bis(silyl)propenes via Copper-Catalyzed Double Proto-Silylations of Polar Enynes
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https://figshare.com/articles/dataset/Catalytically_Asymmetric_Synthesis_of_1_3-Bis_silyl_propenes_via_Copper-Catalyzed_Double_Proto-Silylations_of_Polar_Enynes/6241883
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资源简介：
A copper-catalyzed
double proto-silylations of electron-deficient
conjugated enynes to synthesize functional bis(silyl)propenes was
developed. Under mild reaction conditions, the silylboronate PhMe2Si-Bpin reacts with the enynes via cascade proto-silylations
and yields the corresponding Z-specific bis(silyl)propene
products in up to 98% yield and 95% ee. In addition, the enantioselective
synthesis of these compounds was also achieved by using enantiopure
pyridine-oxazoline-based ligand.
创建时间：
2018-05-09
