Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW9
收藏Protein Data Bank Japan2024-01-24 更新2026-03-21 收录
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Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW9 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-4-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]t rideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]benzamide Authors: Joerger, A.C, Balourdas, D.I, Weiser, T, Chatterjee, D, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2020-04-17 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. Int.J.Cancer, 147, 2020
创建时间：
2020-04-17
