Effect of artemisinin derivatives on the expression of genes related to oral tongue squamous cell carcinoma

To investigate the mechanism of artemisinin derivatives in the treatment of oral tongue squamous carcinoma, we treated Cal-27 oral tongue squamous carcinoma cells with artemisinin derivative (DHA) for 48 hours. The results indicated that DHA effectively inhibited the secretion of PDGF-BB by tumor cells, thereby weakening the tumor cells' reprogramming effects on the tumor microenvironment. This finding provides new theoretical support for the anti-tumor mechanisms of natural product derivatives. Overall design: Cal-27 cells were exposed to DHA and DMSO for 48 hours, and a comparative gene expression profile analysis of the RNA-seq data was performed.