Additional file 2 of Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine

Additional file 2:. Table S1. Table S1. List of purity- and ploidy status of the discovery cohort. Table S2. Sequencing statistics. Table S3. Primer sequences used for Sanger sequencing, pyrosequencing and ddPCR™. Table S4. Sanger sequencing, pyrosequencing and ddPCR™ were used to validate single nucleotide variations detected by whole-exome sequencing. Table S5. List of non-synonymous mutations found in the discovery cohort. Table S6. List of synonymous mutations found in the discovery cohort. Table S7. List of genes with non-synonymous mutations present in the primary tumor of case #5 and its lymph node metastases. Table S8. Distribution of the copy number variants (CNVs), i.e., homozygous or heterozygous deletion and amplification among the 48 tumor samples of the discovery cohort. Table S9. List of cancer cell fraction (CCF) non-synonymous mutations. Table S10. List of genes with ≥2 non-synonymous mutations per case. Table S11. Pathway analysis including copy number variation on the discovery cohort. Table S12. Multivariate analysis. Table S13. Comparison of the prevalence of the single nucleotide variations discovered in our test cohort with published data on gastric cancer [3, 5, 7, 56]. Table S14. List of genes with non-synonymous mutations present in ≥2 cases of the discovery cohort.