Novel role of ALPI gene associated with constipation caused by complement component 3 deficiency

To pinpoint a distinctive gene associated with constipation resulting from C3 deficiency, we conducted microarray hybridization using total RNA extracted from the mid colon of C3 knockout (C3 KO) mice. Identification of causal genes through comparison of gene expression levels in mice induced with C3 deficiency. WT and C3 KO mice is 16 weeks old, and no other treatments.